Rheological assessment of mucolytic agents on sputum of chronic bronchitics

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Rheological assessment of mucolytic agents on sputum of chronic bronchitics.

In vitro and in vivo studies were made on the sputum of chronic bronchitics using a FerrantiShirley cone and plate viscometer and a new stress relaxation method. The latter utilized a modified chemical balance and permitted study at very low shear rates. The results from simpler apparatus correlated well with the data obtained with the cone and plate viscometer. Significant reduction in four ch...

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The effects of mucolytic agents and stirring on sputum viscoelasticity.

Changes in the behavior of sputum viscoelasticity due to differences in macroscopic appearance of sputum brought about by stirring and those due to the addition of an expectorant to purulent sputum in vitro, were studied in a coaxial cylinder rheometer. First, initial results from stirring the sputum indicated the following: Samples of untreated sputum showed no obvious differences among the th...

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Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease.

BACKGROUND Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume and/or purulence of sputum and any therapy that reduced the number of exacerbations would be useful. There is a marked difference between countries in terms of the prescribing of mucolytics depending on whether or not they are perceived to ...

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ژورنال

عنوان ژورنال: Thorax

سال: 1969

ISSN: 0040-6376

DOI: 10.1136/thx.24.6.707